ʻO 17-OH ka hanu a 17-hydroxyprogesterone he hormone steroid i hanaʻia i loko o ka mea ola o ka'aleʻa pāʻokoʻa aʻo ka mua o ia mau hormones e like me cortisol, estradiol a me testosterone. Hiki ke hanaʻia i loko o nā huele o ka wahine, ka'ōmoku'ōpiopio, ke kino melemele a me ka placenta a ma lalo o ka mana o ka enzyme 17-20 lyaly i huli i nā hormones sex. A laila, e noʻonoʻo kākou i ka hana a 17-progesterone i ke kino o kahi wahine hāpaiʻole a me ka hāpaiʻana a me nā hōʻailona o kona ulu a me ka lawaʻole.
ʻO nāʻano pilikino o ka hormone 17-oh progesterone
ʻO ka piʻiʻana o kēlā me kēia kanaka he 17-OH ka hanu i loko o 24 mau hola. No laila,ʻikeʻia ka nui o kaʻikepili i nā hola kakahiaka, a me ke keu - i ka pō. ʻO ka hananaʻana o 17-OH i nā wāhine ma muli o ke kaʻina o ka menstrual cycle. Hoʻonuiʻia ka hoʻonuiʻana i ka pae o kēia hormone i kaʻewa o ka'ōhū (ma mua o ka piʻiʻana o ka hormone luteinizing). ʻO ka hoʻonuiʻiaʻana o 17-OH i ka wā follicular e emi koke ana, e hōʻea ana i kahi liʻiliʻi loa ma ka papa'ōpiopio.
I kēia manawa, e noʻonoʻo i nā kumukūʻau maʻamau o 17-OH progesterone, e pili ana i ka manawa o ka menstrual cycle:
- i ka mahele luteal - 0.99-11.51 nmol / l;
- i ka wā follic - 1,24-8,24 nmol / l;
- i ka manawa o ka anuanu - 0,91-4,24 nmol / l.
He 17-OH ka hanu i ka piʻiʻana o ka'ōpū, e hōʻea ana i kāna mau helu i kauʻia i nā pule hebedoma nei. I loko o ka'ōpūʻana, pane pū ka placenta i ka inoa o kēia hormone steroid. E noʻonoʻo i ka waiwai kūpono o 17-OH i ka wā e hāpai ai:
- i ka makahiki mua - 3,55-17,03 nmol / l;
- i ka lua o nā lā - 3,55-20 nmol / l;
- i ke kolu o ka makahiki - 3.75-33.33 nmol / l.
I loko o ka premenopausal a me ka maleopause, piʻi ka nui o ka hormone 17-OH i ka emi iki a piʻi i kahi 0.39-1.55 nmol / l.
Hoʻololi i ka laulā o 17-OH progesterone - diagnostics and symptoms
ʻO ka nuiʻole o ka 17-OH ka hanu i loko o ke koko,ʻo ia ka kumu o ka hypoplasia adrenal a hiki ke hui pūʻia me ka lawaʻoleʻia o nā hormones. ʻO ka maʻi maʻamau, hiki ke hōʻike iā ia iho ma keʻano o ka maʻi o Addison, a'ōpiopio nā keikikāne i ka genitalia waho.
ʻO ka hoʻonuiʻia o ka hanana 17-OH keʻikeʻia i ka'ōpū wale nō, ma nā mea'ē aʻe, hōʻikeʻia heʻano pilikino. No laila, hiki i ke kūpikipiki kiʻekiʻe 17-OH ke hōʻailona o nā'ōpū o ke kino, nā ovaries (nā hanaʻino a me ka polycystosis) a me nā maʻi o ke kino o ka palekana.
ʻO ka Clinical, hiki ke hoʻonuiʻia ka piʻiʻana o ka hanana 17-OH:
- ka hōʻeha i kaʻaneʻane;
- kaʻikeʻole;
- nā wāwae'ōlohelohe;
- ka wā hānau keiki a me nā'ōpiopio makeʻole;
- hiki ke hoʻonuiʻia i ka hanana 17-OH i nāʻeha (pimples);
- Inā hoʻokiʻekiʻeʻia nā kuʻihuʻi 17-OH, hiki ke hoʻokiʻekiʻeʻia ka testosterone. Hiki keʻike i kēia i keʻano o ka uluʻana o ka lauoho ma ka helehelena a me ke kino.
Hiki ke hoʻoholo i ke kūlana o ka hanana 17-OH i ka nānāʻana i ke kiko
No laila, ua ninaninau mākou i ka hana olala i loko o ke kino o ka hormone 17-OH progesterone a me kāna mau helu i'āponoʻia i nā wahine. ʻO ka emiʻana o ke ana o kēia hormone i keʻano maʻamau wale nō i ka maleopause, aʻo ka hoʻonuiʻana i keʻano he mau no ka'ōpū. ʻO ka hoʻololiʻana o ke kiʻekiʻe o ka 17-OH i ka holoʻana ma nā kumu'ē aʻe paha kahi o nā hōʻailona o ka maʻi maʻamau a me nā maʻi'ōpiopio, e hiki ai i ka hyperandrogenism, iʻole ka maʻiʻole a me nā uluna pōkole.